Foglia Research Group

3400 Spruce Street, Ravdin 8

Division of Neonatology and Newborn Services

Hospital of University of Pennsylvania

Philadelphia, PA 19104

Email: foglia@email.chop.edu

SELECTED PUBLICATIONS

Neonatal Intubation

Heidi M Herrick

In this analysis of 3,145 neonatal intubation encounters, there were important differences in the characteristics and outcomes between intubations that occurred in the delivery room versus neonatal intensive care unit setting.

Neonatology

Neonatal intubation: delivery room vs NICU

Nicole Pouppirt

In this single site retrospective cohort study, video laryngoscopy was independently associated with decreased risk for adverse events during neonatal intubation.

Journal of Pediatrics

Video Laryngoscope and Adverse Intubation Events

Taylor Sawyer

Difficult intubations are common in the NICU and are associated with adverse event and severe oxygen desaturation. Difficult intubations occur more commonly in small preterm infants. The occurrence of a difficult intubation in other neonates is hard to predict due to the lack of sensitivity of bedside screening tests

Arch Dis Child Fetal Neonatal Ed

Difficult intubation prediction for neonatal intubation

Elizabeth Foglia

Adverse TIAEs and severe oxygen desaturation events are common in the NICU setting. Modifiable risk factors associated with TIAEs identified include intubator training level and use of paralytic medications.

Neonatology

Adverse Events During Tracheal Intubation

Elizabeth Foglia

We implemented a novel multisite neonatal intubation registry and identified potentially modifiable factors associated with adverse events.

Pediatrics

Neonatal Intubation Practice and Outcomes

Resuscitation Interventions & Outcomes

Elizabeth Foglia

In this meta-analysis, sustained inflation was associated with similar risks of in-hospital mortality compared with standard therapy. Sustained inflation was associated with increased risk of mortality in the first 2 days compared with standard therapy, and there were no differences in the risk of any other secondary outcomes.

JAMA Pediatrics

Sustained inflation versus standard resuscitation of preterm infants: A systematic review and meta-analysis.

Haresh Kirpalani

In this randomized clinical trial involving 426 infants that was stopped early due to suggestion of harm in the sustained inflation group, there was no significant difference in the rate of bronchopulmonary dysplasia or death at 36 weeks’ postmenstrual age for infants treated with sustained inflation vs standard resuscitation (63.7% vs 59.2%).

JAMA

Effect of Sustained Inflations vs Intermittent Positive Pressure Ventilation on Bronchopulmonary Dysplasia or Death Among Extremely Preterm Infants

Elizabeth Foglia

This inaugural report of over 1,000 delivery room cardiopulmonary resuscitation events in the multi-site American Heart Association Get with the Guidelines-Resuscitation Registry contributes to defining gestational-age specific survival outcomes.

Resuscitation

Survival after delivery room resuscitation: A national registry study.

Elizabeth Foglia

In this article, we review the current evidence for interventions applied during neonatal transition (delivery room and first postnatal hours of life) to prevent BPD in extremely preterm infants: continuous positive airway pressure (CPAP), sustained lung inflation, supplemental oxygen use during neonatal resuscitation, and surfactant therapy including less-invasive surfactant administration

Journal of Perinatology

Delivery room interventions to prevent bronchopulmonary dysplasia in extremely preterm infants

Elizabeth Foglia

In this pilot trial, we demonstrated that intubation and ventilation prior to umbilical cord clamping is safe and feasible among infants with congenital diaphragmatic hernia and may result in short-term physiologic benefit

Arch Dis Child Fetal Neonatal Ed

Initiating resuscitation before umbilical cord clamping in infants with congenital diaphragmatic hernia: a pilot feasibility trial

Elizabeth Foglia

Effective ventilation is the cornerstone of neonatal resuscitation. In this article, we review the physiology of cardiopulmonary transition at birth, with particular attention to factors the caregiver should consider when providing ventilation.

Seminars in Fetal and Neonatal Medicine

Effective ventilation: The most critical intervention for successful delivery room resuscitation.

Monitoring

Heidi Herrick

We adapted a novel tool to measure the impact of Flow Disruptions on practice measures and clinical outcomes during delivery room resuscitation.

Resuscitation

Impact of flow disruptions in the delivery room

Trixie Katz

Wearable eye-tracking technology is feasible to identify gaze fixation on the respiratory function monitor (RFM) display and is well accepted by providers. Neonatal providers look at exhaled tidal volume more than any other RFM parameter.

Arch Dis Child Fetal Neonatal Ed

Visual attention on a respiratory function monitor during simulated neonatal resuscitation: an eye-tracking study

Christopher Bonafide

Smartphone-integrated consumer baby monitors that measure vital signs are popular among parents but are not regulated by the FDA. This study measured the accuracy of pulse oximetry-based consumer baby monitors using an FDA-cleared oximeter as a reference.

JAMA

Accuracy of Pulse Oximetry-Based Home Baby Monitors

Kesi Yang

We studied the impact of "MROPSA" corrective steps on heart rate and tidal volumes during delivery room PPV for preterm infants. Ventilation corrective steps improved tidal volume delivery in some cases but worsened exhaled tidal volumes in others. Mask leak and airway obstruction were induced by some ventilation corrective maneuvers

Archives Disease Childhood Fetal Neonatal Edition

Corrective steps to enhance ventilation in the delivery room

Laura Sillers

PEA may be observed during resuscitation of critically ill newborns, as described in this report. Incor- poration of discrepant physical examination findings and nonpulsatile pulse oximetry waveforms with electronic heart rate monitoring may improve providers’ ability to rapidly recognize PEA.

Neonatology

Pulseless Electrical Activity Complicating Neonatal Resuscitation.

Elizabeth Foglia

We compared pulse oximetry measurement bias between infants with hypoxemia with either dark skin or light skin with Masimo Radical 7 and Nellcor Oximax. There was no significant difference in systematic bias based on skin pigment for either oximeter

Journal of Pediatrics

The Effect of Skin Pigmentation on the Accuracy of Pulse Oximetry in Infants with Hypoxemia

Danielle D. Weinberg

We used eye tracking glasses to assess where team leaders focus their visual attention during neonatal resuscitation. We found systematic differences in eye tracking patterns between neonatologists and neonatal fellows

Resuscitation

Visual attention patterns of team leaders during delivery room resuscitation

Claire Fishman

We assessed the accuracy of real-time delivery room resuscitation documentation. Real-time documentation correctly reflects interventions performed during delivery room resuscitation but is less accurate for early vital sign
assessments.

Arch Dis Child Fetal Neonatal Ed

Accuracy of real-time delivery room resuscitation documentation

Other

Marieke den Boer

This qualitative study of providers’ perceptions of deferred consent for DR studies suggests that a deferred consent approach is acceptable but implementation of this approach can be improved

Arch Dis Child Fetal Neonatal Ed

Deferred consent for delivery room studies: the providers’ perspective

Elizabeth Foglia

We sought to understand the views of international neonatal resuscitation scientists regarding optimal methods of obtaining informed consent for delivery room research

Arch Dis Child Fetal Neonatal Ed

Obtaining informed consent for delivery room research: the investigators’ perspective