Foglia Research Group

We report a longstanding quality improvement project aimed at decreasing intubation for ineffective ventilation for preterm infants after birth

We studied of 3,521 infants who received CPR in the NICU or PICU in the AHA GWTG-Resuscitation registry. Factors most strongly independently associated with death after CPR were vasoactive agent before CPR, initial pulseless condition or development of pulselessness, and NICU location compared with PICU.

In this meta-analysis, sustained inflation was associated with similar risks of in-hospital mortality compared with standard therapy. Sustained inflation was associated with increased risk of mortality in the first 2 days compared with standard therapy, and there were no differences in the risk of any other secondary outcomes.

In this randomized clinical trial involving 426 infants that was stopped early due to suggestion of harm in the sustained inflation group, there was no significant difference in the rate of bronchopulmonary dysplasia or death at 36 weeks’ postmenstrual age for infants treated with sustained inflation vs standard resuscitation (63.7% vs 59.2%).

This Clinical Decisions piece explores universal vs selective neonatal resuscitation at 22 weeks' gestation

In this multicenter cohort of infants receiving chest compressions following delivery, recognizable pre-birth risk factors as well as resuscitation interventions associated with increased and decreased odds of achieving return of spontaneous circulation (ROSC) were identified.

This inaugural report of over 1,000 delivery room cardiopulmonary resuscitation events in the multi-site American Heart Association Get with the Guidelines-Resuscitation Registry contributes to defining gestational-age specific survival outcomes.

In this article, we review the current evidence for interventions applied during neonatal transition (delivery room and first postnatal hours of life) to prevent BPD in extremely preterm infants: continuous positive airway pressure (CPAP), sustained lung inflation, supplemental oxygen use during neonatal resuscitation, and surfactant therapy including less-invasive surfactant administration

We analyzed respiratory function monitor (RFM) and vital sign measurements for infants who received sustained inflation and intermittent positive pressure ventilation (IPPV) in the Sustained Aeration of Infant Lungs (SAIL) trial.

This is an updated ILCOR systematic review of 16 studies including 579 infants with ongoing CPR at 10 minutes after birth. These infants are at high risk for mortality and neurodisability, but survival without moderate or severe neuroimpairment is possible. One specified duration of CPR is unlikely to uniformly predict survival or survival without neuroimpairment.

In this pilot trial, we demonstrated that intubation and ventilation prior to umbilical cord clamping is safe and feasible among infants with congenital diaphragmatic hernia and may result in short-term physiologic benefit

Effective ventilation is the cornerstone of neonatal resuscitation. In this article, we review the physiology of cardiopulmonary transition at birth, with particular attention to factors the caregiver should consider when providing ventilation.